Biological applications of ionophores

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August undefined, 2024

WebThe structure and physical chemical properties are reviewed of various ionophores, small molecules which transport cations across biological membranes. The subclass of carboxylic ionophores has dramatic pharmacological properties, dilating the coronary arteries and increasing cardiac contractility, which make them especially interesting. WebAbstract. Ionophores are substances which facilitate the movement of ions into and/or through organic phases. The two major classes of compounds are the neutral ionophores, which form charged clathrate complexes with ions, and the carboxylic polyether ionophores which are neutral in the complexed state. Many of the ionophores exclusively bind ...

Ion‐Selective Electrodes Based on Hydrophilic Ionophore‐Modified ...

WebIonophores are compounds that form lipid soluble, dynamically reversible complexes with cations and by this means facilitate specific ionic transport across biologic membranes (Pressman, 1976; Reed, 1982; Taylor et al., 1982 ). There are two major subclasses of ionophores, (1) neutral ionophores, which are highly toxic because they form charged ... WebJan 24, 2024 · DNA based ionophores can mediate efficient ion transport and are crucial to understand the biological role of their natural counterparts. Here authors engineer a telomeric DNA G-quadruplex based ... csu antigen testing

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WebAs it has turned out, medical and pharmaceutical applications of ionophores are limited, since the activity of ionophores is not restricted to microbial membranes. On the other hand, ionophores were found to be wonderful tools in biochemical research at the cellular or membrane level. ... Pressman, B.C.: Biological applications of ionophores ... WebThe control of ion transport and homeostasis is a critical function of living organisms. In this perspective, an overview of different synthetic systems capable of facilitating the transmembrane transport of ions along with the biological activity exerted by these compounds is presented. Examples of both cat WebJan 15, 2000 · Monopodal and oligopodal Mg2+-selective ionophores were characterized by their selectivity coefficients (Separate Solution Method, SSM) in plasticized poly ... “Chemical Sensors and Biosensors for Medical and Biological Applications”, 1998, Wiley–VCH, Weinheim. M. Müller, M. Rouilly, B. Rusterholz, M. Maj-Zurawska, Z. Hu, … csu animal ethics

Biomedical applications of copper ionophores

WebNatural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to … WebMay 27, 2024 · Despite several ionophores revealing potential therapeutic applications as apoptosis inducers, ... In the context of transporting molecules of biological relevance, quite a few ionophores have been … csu application deadlines for fall 2022WebAnalogous ionophores have now been synthesized. Unique applications for these compounds are emerging, based either on their selective toxicity or ability to modify … csu and uc schools

"WebIonophores are a class of compounds that form complexes with specific ions and facilitate their transport across cell membranes. An ionophore typically has a hydrophilic pocket (or hole) that forms a binding site specific for a particular ion. The exterior surface of an ionophore is hydrophobic, allowing the complexed ion in its pocket to cross the … " - Biological applications of ionophores

Biological applications of ionophores

Biological Applications and Evolutionary Origins of …

WebIonophores transport ions across biological membranes and have wide-ranging applications, but a platform for their rapid development does not exist. We report a platform for developing ionophores from metal-ion chelators, which are readily available with wide-ranging affinities and specificities, and structural data that can aid rational design. WebThe Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …

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WebApr 6, 2024 · Ionophores transport ions across biological membranes and have wide-ranging applications, but a platform for their rapid development does not exist. We report a platform for developing ionophores from metal-ion chelators, which are readily available with wide-ranging affinities and specificities, and structural data that can aid rational design. WebJan 1, 2024 · Biological Applications of Ionophores. Article. Feb 1976; Berton C. Pressman; View. Effects of a low protein diet during pregnancy of the rhesus monkey. I. Reproductive efficiency. Article.

WebMay 27, 2024 · A comprehensive investigation of the structure-activity relationships, selectivity aspects and biological implications in terms of potential therapeutic applications of these ionophores will be … WebBiological applications and evolutionary origins of ionophores. Pressman BC , deGuzman NT Adv Exp Med Biol, 84:285-300, 01 Jan 1977 Cited by: 6 articles PMID: …

WebAs it has turned out, medical and pharmaceutical applications of ionophores are limited, since the activity of ionophores is not restricted to microbial membranes. On the other … WebPressman BC (1976) Biological applications of ionophores. Ann Rev Biochem 45:501–530. CrossRef PubMed CAS Google Scholar Puskin JS, Gunter TE (1975) Electron paramagnetic resonance of copper ion and manganese ion complexes with the ionophore A23187. Biochemistry 14:187–191 . CrossRef ...

WebPolyether ionophores are complex natural products capable of transporting cations across biological membranes. Many polyether ionophores possess potent antimicrobial activity and a few selected compounds have the ability to target aggressive cancer cells. Nevertheless, ionophore function is believed …

WebMar 4, 2024 · Cu ionophores include HQs that have a vast variety of biological applications. The most known compound of the HQ class is 7-iodo- 5-chloro-8-hydroxyquinoline (CQ) that was first used as an antibiotic and more recently has been studied for the repurposing in different diseases ranging from neurodegenerative … early pregnancy stomach 3 weeksWebDec 21, 2024 · Zinc ionophores increase the intracellular concentration of Zinc ions causing significant biological effects. This review provides, for the first time, an overview of the … early pregnancy stringy dischargeWebThe control of ion transport and homeostasis is a critical function of living organisms. In this perspective, an overview of different synthetic systems capable of facilitating the … early pregnancy stomach painsWebAug 13, 2024 · Labile zinc, a tiny fraction of total intracellular zinc that is loosely bound to proteins and easily interchangeable, modulates the activity of numerous signaling and … csu application checklistWebFeb 15, 2015 · 6 Structure and Biological Activity of Polyether Ionophores and Their. ... Practical applications The present study is the first to study the effect of M. longifolia in an experimental model of ... early pregnancy stomach soundsWebMar 4, 2024 · The development of new therapeutic agents should aim to increase selectivity and therefore reduce side effects. In addition, these agents should overcome cancer cell resistance and target cancer ... csu application downWebNov 1, 2024 · Ionophores transport ions across biological membranes and have wide‐ranging applications, but a platform for their rapid development does not exist. early pregnancy stomach tightening