Nettet1. jun. 2024 · The transcription factors Blimp-1 and Id2 induce terminal differentiation thus promoting CD8 + T cells differentiation into T EM cells, whereas Id3 correlates with the upregulation of Il-7r, Sell, Il2, Bcl2, and Ccr7, genes essential for the differentiation of CD8 + T cells into a T CM phenotype [ [41], [42], [43] ]. Nettet13. sep. 2024 · Hobit and Blimp1 are the central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations. Using RNA and protein expression profiling at single-cell resolution in mouse cells, Chihara et al. (2024) identified a module of coinhibitory receptors that includes not only several known …
Hobitit - Wikipedia
Nettet15. jul. 2015 · Hobit was able to function as a transcriptional repressor that recognized the same target sites as Blimp-1, suggesting overlapping roles for the homologous … NettetAbout Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features Press Copyright Contact us Creators ... by hop-o\u0027-my-thumb
Hobit and Blimp1 instruct a universal transcriptional program
NettetWe examined the expression regulation of Hobit and Blimp-1 in murine and human CD8 T-cells to determine their timeframe of activity. While Blimp-1 mRNA was expressed throughout effector and memory T cells, Blimp-1 protein, was only transiently expressed during the effector stage. NettetHobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Laura K Mackay, Martina Minnich, Natasja AM Kragten, Yang Liao, … Nettet22. apr. 2016 · Hobit and Blimp1 are highly homologous in their DNA-binding zinc finger domains ( 2, 23 ), which suggested overlapping roles in transcriptional regulation. To … by hook or by crook meaning in tamil