WebJan 1, 2015 · The DAF can range from rudimentary algorithms with a minimal number of parameters that accommodate sparse databases, to more sophisticated biologically-based dose-response (BBDR) model structures with detailed mechanistic descriptions of tissue responses. ( 4 , 23 , 27 ) In addition to the DAF, uncertainty factors are often employed to … WebMar 8, 2024 · EPA stated in the Final Risk Evaluation for PV29 that “The [Regional Deposited Dose Ratio (RDDR)] software was utilized for dosimetric adjustment across species instead of the multi-path particle dosimetry (MPPD) model because the MPPD software cannot calculate the DAF for hamsters tested in the Elder et al., (2005) study.”
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MPPD: Multiple-Path Particle Dosimetry Model - ARA
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